Electrospinning of Quaternized Chitosan-Poly(vinyl alcohol) Composite Nanofiber Membrane: Processing Optimization and Antibacterial Efficacy

Membranes

Kuei-Hsiang Chen¹  Yu-Kaung Chang¹  Jheng-Yu Wu¹  Chen-Yaw Chiu¹  You-Ren Lai²  Hung-Che Lee³  Chi-Yun Wang⁴ 

[1] Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan;Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan;Falco Tech Enterprise Co., Ltd., Tucheng Dist., New Taipei City 23674, Taiwan;International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City 243303, Taiwan;

关键词: nanofiber membrane;    chitosan;    HTCC;    polyvinyl alcohol;    antibacterial;    Escherichia coli;   

DOI  :  10.3390/membranes12030332

来源: DOAJ

【 摘 要 】

N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride (HTCC) is a type of quaternary ammonium chitosan derivative with an antibacterial activity superior to the pristine chitosan, but its electrospinnability is limited. In this study, polyvinyl alcohol (PVA) was blended with HTCC to improve the electrospinnability of nanofibers. The electrospinning of PVA–HTCC nanofiber membranes was optimized in terms of structural stability and antimicrobial performance. Based on scanning electron microscopic analysis, the morphology and diameter of the produced nanofibers were influenced by the applied voltage, flow rate of the feed solution, and weight ratio of the polymer blend. An increase in the HTCC content decreased the average nanofiber diameter. The maximum water solubility of the PVA–HTCC nanofibers reached the maximum value of 70.92% at 12 h and 25 °C. The antibacterial activity of PVA–HTCC nanofiber membranes against Escherichia coli was ~90%, which is significantly higher than that of PVA–chitosan nanofiber membrane. Moreover, the antibacterial efficiency of PVA–HTCC nanofiber membranes remained unaffected after 5 cycles of antibacterial treatment. The good antibacterial performance and biocompatibility of PVA–HTCC nanofiber membrane makes them attractive for biomedical and biochemical applications that necessitate sterile conditions.

【 授权许可】

Unknown