Human Milk Oligosaccharides (HMOs) and Infant Microbiota: A Scoping Review

Foods

María Paz Lorenzo¹  Cristina Sánchez¹  Alexandre Lamas²  Patricia Regal²  Cristina Fente² 

[1] Center for Metabolomics and Bioanalysis (CEMBIO), Facultad de Farmacia, Campus Montepríncipe, Universidad San Pablo-CEU, Boadilla del Monte, 28668 Madrid, Spain;Department of Analytical Chemistry, Nutrition and Bromatology, Santiago de Compostela University, 27002 Lugo, Spain;

关键词: breast milk;    breastfeeding;    human milk oligosaccharide;    infant gut microbiota;    microbiome;   

DOI  :  10.3390/foods10061429

来源: DOAJ

【 摘 要 】

Human milk oligosaccharides (HMOs) are the third most abundant solid component of breast milk. However, the newborn cannot assimilate them as nutrients. They are recognized prebiotic agents (the first in the newborn diet) that stimulate the growth of beneficial microorganisms, mainly the genus Bifidobacterium, dominant in the gut of breastfed infants. The structures of the oligosaccharides vary mainly according to maternal genetics, but also other maternal factors such as parity and mode of delivery, age, diet, and nutritional status or even geographic location and seasonality cause different breast milk oligosaccharides profiles. Differences in the profiles of HMO have been linked to breast milk microbiota and gut microbial colonization of babies. Here, we provide a review of the scope of reports on associations between HMOs and the infant gut microbiota to assess the impact of HMO composition.

【 授权许可】

Unknown