Prefrontal synaptic activation during hippocampal memory reactivation

Cell Reports

Takuya Sasaki¹  Yuji Ikegaya²  Yuya Nishimura² 

[1] Center for Information and Neural Networks, National Institute of Information and Communications Technology, 1-4 Yamadaoka, Suita City, Osaka 565-0871, Japan;Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;

关键词: hippocampus;    prefrontal cortex;    patch-clamp recording;    synchronization;    place cell;    synapse;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Cooperative reactivation of hippocampal and prefrontal neurons is considered crucial for mnemonic processes. To directly record synaptic substances supporting the interregional interactions, we develop concurrent spike recordings of hippocampal neuronal ensembles and whole-cell patch-clamp recordings of medial prefrontal neurons in awake rats. We find that medial prefrontal neurons depolarize when hippocampal neurons synchronize. The depolarization in medial prefrontal neurons is larger when hippocampal place cells that encoded overlapping place fields and place cells that encoded a novel environment are synchronously reactivated. Our results suggest a functional circuit-synapse association that enables prefrontal neurons to read out specific memory traces from the hippocampus.

【 授权许可】

Unknown