New Insights into Cellular Impacts of Metals in Aquatic Animals

Environments

Elise David¹  Stéphane Betoulle¹  Iris Barjhoux¹  Claudia Cosio¹  Florence Bultelle²  Aimie Le Saux²  Béatrice Rocher² 

[1] INERIS, SEBIO UMR I02, Université de Reims Champagne Ardenne, 51097 Reims, France;UMR I-02 SEBIO, Normandie Univ, UNIHAVRE, FR CNRS 3730 SCALE, 76600 Le Havre, France;

关键词: bivalve;    cytoskeleton rearrangement;    free cellular energy and mitochondrial metabolism;    metabolism reshuffle;    redox homeostasis;    stress protein;   

DOI  :  10.3390/environments7060046

来源: DOAJ

【 摘 要 】

Toxic metals remain a current important threat to aquatic ecosystems, despite regulatory efforts to reduce their release. Several toxic metals already appear in the list of priority substances polluting surface waters, while concerns arise from the increasing use of technology-critical metals such as metallic nanoparticles, rare-earth, and platinum group metals. In aquatic environments, various chemical, biological and physical processes determine the impact of metals on the biota. This review provides insights into responses to toxic metals recently reported in freshwater and marine animals. The specific emphasis is on: (i) common cellular and molecular responses; (ii) stress proteins; (iii) redox homeostasis; (iv) cytoskeleton rearrangement; (v) metabolism reshuffle; (vi) free cellular energy and mitochondrial metabolism; and (vi) immunity. These endpoints are promising, notably in multi-biomarker approaches to identify precise cellular toxicity pathways and anticipate the impact of environmental metal pollution.

【 授权许可】

Unknown