Depression and Cardiovascular Disease: The Viewpoint of Platelets

International Journal of Molecular Sciences

Alessandro Ieraci¹  Leonardo Sandrini²  SilviaStella Barbieri²  Marta Zarಠ Patrizia Amadio² 

[1] Laboratory of Neuropsychopharmacology and Functional Neurogenomics, Department of Pharmaceutical Sciences, University of Milan, Milan 20133, Italy;Unit of Brain-Heart Axis: cellular and molecular mechanism, Centro Cardiologico Monzino IRCCS, Milan 20138, Italy;

关键词: platelets;    depression;    catecholamines;    adipokines;    low density lipoproteins;    reactive oxygen species;   

DOI  :  10.3390/ijms21207560

来源: DOAJ

【 摘 要 】

Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.

【 授权许可】

Unknown