Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

Acta Pharmaceutica Sinica B

Tan Yang¹  Robert J. Lee²  Xiaojuan Zhang³  Ting Fan³  Yao Lu³  Guangya Xiang³  Ruicong Yan³  Muhammad Sarfraz³  Chen Chen³  Xiang Ma³  Pengxuan Zhao³  Minsi Li³  Muhammad Waseem Khan³  Yan Chen³  Chuanchuan He³ 

[1] Corresponding authors. Tel./fax: [phone].;College of Pharmacy, the Ohio State University, Columbus, OH 43210, USA;School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;

关键词: Platinum;    Curcumin;    Complex;    Nanoparticles;    Non-small cell lung cancer;    Anti-metastasis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC). However, it has side effects and minimum efficacy against lung cancer metastasis. In this study, platinum–curcumin complexes were loaded into pH and redox dual-responsive nanoparticles (denoted as Pt–CUR@PSPPN) to facilitate intracellular release and synergistic anti-cancer effects. Pt–CUR@PSPPN was prepared by a nano-precipitation method and had a diameter of ∼100 nm. The nanoparticles showed increased anti-cancer effects both in vivo and in vitro. In addition, Pt–CUR@PSPPN blocked PI3K/AKT signal transduction pathway and inhibited MMP2 and VEGFR2, resulting in enhanced anti-metastatic activity. Furthermore, reduced side effects were also observed. In conclusion, Pt–CUR@PSPPN provided a novel and attractive therapeutic strategy for NSCLC.

【 授权许可】

Unknown