Severe Salmonella spp. or Campylobacter spp. Infection and the Risk of Biliary Tract Cancer: A Population-Based Study

Cancers

Rachel van der Post¹  Elise de Savornin Lohman²  Philip de Reuver²  Bas Groot Koerkamp³  Eelco Franz⁴  Lapo Mughini Gras⁴  Janneke Duijster⁴ 

[1] Department of Pathology, Radboud University Medical Center, P.O. Box 9101, 6500 Nijmegen, The Netherlands;Department of Surgery, Radboud University Medical Center, P.O. Box 9101, 6500 Nijmegen, The Netherlands;Institute for Risk Assessment Sciences, Utrecht University, P.O. Box 80125, 3508 Utrecht, The Netherlands;National Institute for Public Health and the Environment, P.O. Box 1, 3720 Bilthoven, The Netherlands;

关键词: bacterial infection;    cancer;    epidemiology;    risk factor;   

DOI  :  10.3390/cancers12113348

来源: DOAJ

【 摘 要 】

Salmonella spp. infection has shown to have oncogenic transformative effects and thereby increases the risk of certain cancers. For Campylobacter spp., similar effects have been demonstrated. Risk factor identification may allow for timely diagnosis and preventive treatment. To substantiate the oncogenic potential of Salmonella and Campylobacter spp., this study compared the incidence of extrahepatic biliary tract cancer (BTC) in patients with diagnosed Salmonella or Campylobacter spp. infection with BTC incidence in the Netherlands. National infectious diseases surveillance records of patients diagnosed with a laboratory-confirmed Salmonella or Campylobacter spp. infection during 1999–2016 were linked to the Netherlands Cancer Registry. Incidence of BTC in Salmonella and Campylobacter spp. patients was compared to the incidence of BTC in the general population using Standardized Incidence Ratios (SIRs). In total, 16,252 patients were diagnosed with Salmonella spp. and 27,668 with Campylobacter spp. infection. Nine patients developed BTC at a median of 46 months (13–67) after Salmonella spp. infection and seven at a median of 60 months (18–138) after Campylobacter spp. infection. SIR of BTC in salmonellosis patients was 1.53 (95% CI 0.70–2.91). In patients aged <60 years, the SIR was 1.74 (95% CI 0.36–5.04). For campylobacteriosis patients, the SIR was 0.97 (95% CI 0.39–2.00). Even though Salmonella or Campylobacter spp. infection was not significantly associated with increased BTC risk in this cohort, it remains extremely important to study potential risk factors for cancer to facilitate screening and ultimately improve prognosis of cancer patients.

【 授权许可】

Unknown