Next Generation Cancer Vaccines—Make It Personal!

Vaccines

Juanita Lopez¹  Angelika Terbuch¹ 

[1] Drug Development Unit, Royal Marsden Hospital and The Institute of Cancer Research, Sutton SM2 5PT, UK;

关键词: cancer vaccines;    immunotherapy;    combination strategies;    cancer immunity cycle;    neoantigens;    personalized cancer vaccine;   

DOI  :  10.3390/vaccines6030052

来源: DOAJ

【 摘 要 】

Dramatic success in cancer immunotherapy has been achieved over the last decade with the introduction of checkpoint inhibitors, leading to response rates higher than with chemotherapy in certain cancer types. These responses are often restricted to cancers that have a high mutational burden and show pre-existing T-cell infiltrates. Despite extensive efforts, therapeutic vaccines have been mostly unsuccessful in the clinic. With the introduction of next generation sequencing, the identification of individual mutations is possible, enabling the production of personalized cancer vaccines. Combining immune check point inhibitors to overcome the immunosuppressive microenvironment and personalized cancer vaccines for directing the host immune system against the chosen antigens might be a promising treatment strategy.

【 授权许可】

Unknown