The morphological changes in the internal organs of laboratory animals after prolonged oral administration of gold nanoparticles

Journal of Innovative Optical Health Sciences

Vladimir A. Bogatyrev¹  Nikolai G. Khlebtsov¹  Boris N. Khlebtsov¹  Valery V. Tuchin²  Irina O. Bugaeva³  Nikita A. Navolokin³  Alla B. Bucharskaya³  Svetlana S. Pakhomy³  Galina N. Maslyakova³  Olga V. Zlobina³ 

[1] Institute of Biochemistry and Physiology of Plants and Microorganisms RAS, 410049 Saratov, Russia;Research-Educational Institute of Optics and Biophotonics, Saratov National Research State University, 410012 Saratov, Russia;Saratov State Medical University n.a.V.I. Razumovsky, 410012 Saratov, Russia;

关键词: Gold nanoparticles;    prolonged peroral administration;    morphological changes;    reversibility;   

DOI  :  10.1142/S1793545816420049

来源: DOAJ

【 摘 要 】

Recently gold nanoparticles (GNPs) have been actively studied as photothermal converters, drug carriers, and imaging agents in a wide range of applications in cancer diagnosis and therapy. The prolonged peroral administration of GNPs in a range of sizes was performed to investigate the morphological changes and their reversibility in the internal organs of laboratory animals. In this study, GNPs with average diameters of 2nm, 15nm and 50nm were administered during 30 days, and the reversibility of morphological changes was investigated 14 days after administration. After the prolonged administration of GNPs, the severity of morphological changes in the liver, kidney, spleen and lymph nodes depended on the nanoparticle size. Specifically, 50nm nanoparticles caused the most pronounced dystrophic and necrobiotic effects, whereas the smallest 2nm nanoparticles caused proliferative changes. Most importantly, the development of pathological processes was reversible, as evidenced by the gradual restoration of the organ structure at 14 days after the end of GNPs administration.

【 授权许可】

Unknown