Significance of NPM1 Gene Mutations in AML

International Journal of Molecular Sciences

Mary Frances McMullin¹  Andrew Hindley²  Mark Alexander Catherwood²  Ken I. Mills³ 

[1] Centre for Medical Education, Queen’s University Belfast, Belfast BT7 1NN, UK;Clinical Haematology, Belfast City Hospital, Belfast BT9 7AB, UK;Patrick G Johnston Center for Cancer Research, Queens University Belfast, Belfast BT9 7AE, UK;

关键词: AML;    NPM1;    fragment analysis;    FLT3;    DNMT3A;   

DOI  :  10.3390/ijms221810040

来源: DOAJ

【 摘 要 】

The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly witnessed in NPM1, and the mechanism by which this influences the development and progression of AML. The importance of NPM1 mutation on prognosis and the treatment options available to patients will also be reviewed along with current guidelines recommending the rapid return of NPM1 mutational screening results and the importance of employing a suitable laboratory assay to achieve this. Finally, future developments in the field including research into new therapies targeting NPM1 mutated AML are considered.

【 授权许可】

Unknown