Infusion Reactions Associated with the Medical Application of Monoclonal Antibodies: The Role of Complement Activation and Possibility of Inhibition by Factor H

Antibodies

Mihály Józsi¹  Tamás Fülöp²  János Szebeni²  Gergely Tibor Kozma²  Tamás Mészáros² 

[1] Complement Research Group, Department of Immunology, ELTE Eötvös Loránd University, 1117 Budapest, Hungary;Nanomedicine Research and Education Center, Semmelweis University, 1089 Budapest, Hungary;

关键词: CARPA;    complement;    complement activation;    factor H;    hypersensitivity;    infusion reaction;    monoclonal antibody therapy;    pseudoallergic reaction;   

DOI  :  10.3390/antib7010014

来源: DOAJ

【 摘 要 】

Human application of monoclonal antibodies (mAbs), enzymes, as well as contrast media and many other particulate drugs and agents referred to as “nanomedicines”, can initiate pseudoallergic hypersensitivity reactions, also known as infusion reactions. These may in part be mediated by the activation of the complement system, a major humoral defense system of innate immunity. In this review, we provide a brief outline of complement activation-related pseudoallergy (CARPA) in general, and then focus on the reactions caused by mAb therapy. Because the alternative pathway of complement activation may amplify such adverse reactions, we highlight the potential use of complement factor H as an inhibitor of CARPA.

【 授权许可】

Unknown