Microbiota medicine: towards clinical revolution

Journal of Translational Medicine

Chantal Pichon¹  Paulina Samczuk²  Marvin Edeas³  Carole Nicco³  Cristina Giaroni⁴  Markus Egert⁵  Matteo Serino⁶  Prisca Gebrayel⁷  Annalisa Terranegra⁸  Souhaila Al Khodor⁸  Jaroslaw Bilinski⁹  Marcin Ufnal⁹  Mariusz Sikora^1,10  Igor Loniewski^1,11  Tomasz M. Karpinski^1,12  Peter Konturek^1,13  Romain Villeger^1,14  Elisabetta Caselli^1,15  Elena M. Comelli^1,16  Julie Reygner^1,17  Agata Mulak^1,18 

[1] Center for Molecular Biophysics CNRS UPR 4301, University of Orléans;Clinical Research Centre, Medical University of Bialystok;Department Endocrinology, Metabolism and Diabetes, Faculté de Médecine Cochin-Port Royal, Université de Paris, INSERM U1016, Institut Cochin;Department of Medicine and Surgery, University of Insubria;Furtwangen University;IRSD, Université de Toulouse, INSERM, INRAE, ENVT, UPS;International Society of Microbiota;Maternal and Child Health Department, Research Branch, Sidra Medicine;Medical University of Warsaw;National Institute of Geriatrics, Rheumatology and Rehabilitation;Pomeranian Medical University;Poznań University of Medical Sciences;Teaching Hospital of the University of Jena;University of Clermont Auvergne;University of Ferrara;University of Toronto;Université Paris Descartes;Wroclaw Medical University;

关键词: Dysbiosis;    Built environment microbiome;    Metabolites;    miRNAs;    Fecal microbiota transplant;    Prebiotics;   

DOI  :  10.1186/s12967-022-03296-9

来源: DOAJ

【 摘 要 】

Abstract The human gastrointestinal tract is inhabited by the largest microbial community within the human body consisting of trillions of microbes called gut microbiota. The normal flora is the site of many physiological functions such as enhancing the host immunity, participating in the nutrient absorption and protecting the body against pathogenic microorganisms. Numerous investigations showed a bidirectional interplay between gut microbiota and many organs within the human body such as the intestines, the lungs, the brain, and the skin. Large body of evidence demonstrated, more than a decade ago, that the gut microbial alteration is a key factor in the pathogenesis of many local and systemic disorders. In this regard, a deep understanding of the mechanisms involved in the gut microbial symbiosis/dysbiosis is crucial for the clinical and health field. We review the most recent studies on the involvement of gut microbiota in the pathogenesis of many diseases. We also elaborate the different strategies used to manipulate the gut microbiota in the prevention and treatment of disorders. The future of medicine is strongly related to the quality of our microbiota. Targeting microbiota dysbiosis will be a huge challenge.

【 授权许可】

Unknown