Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition

Frontiers in Cell and Developmental Biology

Huaxi Xu¹  Xia Liu²  Yash Nayak²  Cindy Wang²  Guangyong Peng²  Fusheng Si²  Lan Huang²  Bo Peng²  Jie Dou³ 

[1] Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China;Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, School of Medicine, Saint Louis University, St. Louis, MO, United States;State Key Laboratory of Natural Medicines, School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China;

关键词: baicalein;    baicalin;    melanoma;    N-RAS;    B-RAF;    apoptosis;   

DOI  :  10.3389/fcell.2020.00836

来源: DOAJ

【 摘 要 】

Malignant melanoma is one of the most common and dangerous skin cancers with a high rate of death every year. Furthermore, N-RAS and B-RAF mutations in melanoma cells increase the difficulties for clinical treatment in patients. Therefore, development of effective and universal drugs against melanoma is urgently needed. Here we demonstrate that baicalein and baicalin, the active components of the Chinese traditional medicinal plant Scutellaria baicalensis Georgi, can significantly inhibit melanoma cell growth and proliferation, suppress tumor cell colony formation and migration, as well as induce apoptosis and senescence in melanoma cells. The anti-tumor effects mediated by baicalein and baicalin are independent of N-RAS and B-RAF mutation statuses in melanoma cells. Mechanistically, we identify that the suppression of baicalein and baicalin on melanoma cells is due to inhibition of tumor cell glucose uptake and metabolism by affecting the mTOR-HIF-1α signaling pathway. In addition, we demonstrated that baicalein and baicalin can suppress tumorigenesis and tumor growth in vivo in the melanoma model. These studies clearly indicate that baicalein and baicalin can control tumor growth and development metabolically and have great potential as novel and universal drugs for melanoma therapy.

【 授权许可】

Unknown