Functional Assessment for Acute Stroke Trials: Properties, Analysis, and Application

Frontiers in Neurology

关键词: stroke;    outcome;    disability;    modified Rankin scale;    Barthel index;    NIHSS;   

DOI  :  10.3389/fneur.2018.00191

来源: DOAJ

【 摘 要 】

A measure of treatment effect is needed to assess the utility of any novel intervention in acute stroke. For a potentially disabling condition such as stroke, outcomes of interest should include some measure of functional recovery. There are many functional outcome assessments that can be used after stroke. In this narrative review, we discuss exemplars of assessments that describe impairment, activity, participation, and quality of life. We will consider the psychometric properties of assessment scales in the context of stroke trials, focusing on validity, reliability, responsiveness, and feasibility. We will consider approaches to the analysis of functional outcome measures, including novel statistical approaches. Finally, we will discuss how advances in audiovisual and information technology could further improve outcome assessment in trials.

【 授权许可】

Unknown