Polymorphism of μ1-opioid receptor (OPRM1) gene may be of value in genesis of renal malignant neoplasm

Onkourologiâ

A. V. Boiarkina¹  S. A. Ivanov¹  N. Yu. Novikov¹  A. D. Kaprin¹  A. L. Potapov¹  I. P. Kostyuk¹  R. R. Gevorkyan² 

[1] A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia;N.A. Semashko Republican Clinical Hospital;

关键词: μ1-opioid receptor;    polymorphism;    renal neoplasm;   

DOI  :  10.17650/1726-9776-2019-15-3-42-45

来源: DOAJ

【 摘 要 】

Objective: to evaluate alleles distribution of single nucleotide polymorphism 118A>G of μ1-opioid receptor (OPRM1) gene in patients with renal neoplasm and benign diseases.Materials and methods. 100 consecutive patients after renal surgeries retrospectively divided into groups with neoplasm (n = 29) and benign diseases (n = 71).Results. The incidence of renal neoplasm was much higher in homozygous 118A patients than in AG + GG group (36.4 % vs. 14.7 %; p = 0.035).Conclusion. Single nucleotide polymorphism 118A>G OPRM1 gene may be of value in genesis of renal neoplasm.

【 授权许可】

Unknown