Midnolin Regulates Liver Cancer Cell Growth In Vitro and In Vivo

Cancers

Wendong Huang¹  Soo-Mi Kweon²  Gayeoun Kim²  Keane K. Y. Lai²  Yunseong Jeong³  Ju-Seog Lee³ 

[1] Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;

关键词: midnolin;    hepatocellular carcinoma;    liver cancer;    liver carcinogenesis;   

DOI  :  10.3390/cancers14061421

来源: DOAJ

【 摘 要 】

Hepatocellular carcinoma (HCC) ranks worldwide as one of the most lethal cancers. In spite of the vast existing knowledge about HCC, the pathogenesis of HCC is not completely understood. Discovery of novel genes that contribute to HCC pathogenesis will provide new insights for better understanding and treating HCC. The relatively obscure gene midnolin has been studied for over two decades; however, its biological roles are largely unknown. Our study is the first to demonstrate the functional significance of midnolin in HCC/cancer: Midnolin expression correlates with poor prognosis in HCC patients, and suppression of midnolin severely inhibits tumorigenicity of HCC cells in vitro and in mice and disrupts retinoic acid/lipid metabolism in these cells.

【 授权许可】

Unknown