Targeting MicroRNAs in Cancer Gene Therapy

Genes

Bin Sun¹  Weidan Ji²  Changqing Su² 

[1] National Center of Liver Cancer, Second Military Medical University, Shanghai 200433, China;;Department of Molecular Oncology, Eastern Hepatobiliary Surgery Hospital &

关键词: cancer;    microRNA;    gene therapy;    oncogene;    tumor suppressor gene;   

DOI  :  10.3390/genes8010021

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) are a kind of conserved small non-coding RNAs that participate in regulating gene expression by targeting multiple molecules. Early studies have shown that the expression of miRNAs changes significantly in different tumor tissues and cancer cell lines. It is well acknowledged that such variation is involved in almost all biological processes, including cell proliferation, mobility, survival and differentiation. Increasing experimental data indicate that miRNA dysregulation is a biomarker of several pathological conditions including cancer, and that miRNA can exert a causal role, as oncogenes or tumor suppressor genes, in different steps of the tumorigenic process. Anticancer therapies based on miRNAs are currently being developed with a goal to improve outcomes of cancer treatment. In our present study, we review the function of miRNAs in tumorigenesis and development, and discuss the latest clinical applications and strategies of therapy targeting miRNAs in cancer.

【 授权许可】

Unknown