The Role of Autophagy and Pyroptosis in Liver Disorders

International Journal of Molecular Sciences

Huijie Zhao¹  Honggang Wang²  Yihan Yang²  Huiyang Liu² 

[1] Institute of Chronic Disease Risks Assessment, Henan University, Kaifeng 475004, China;School of Basic Medical Sciences, Henan University, Kaifeng 475004, China;

关键词: autophagy;    pyroptosis;    non-alcoholic fatty liver disease;    hepatocellular carcinoma;    hepatotoxicity;   

DOI  :  10.3390/ijms23116208

来源: DOAJ

【 摘 要 】

Pyroptosis is a programmed cell death caused by inflammasomes, which can detect cell cytosolic contamination or disturbance. In pyroptosis, caspase-1 or caspase-11/4/5 is activated, cleaving gasdermin D to separate its N-terminal pore-forming domain (PFD). The oligomerization of PFD forms macropores in the membrane, resulting in swelling and membrane rupture. According to the different mechanisms, pyroptosis can be divided into three types: canonical pathway-mediated pyroptosis, non-canonical pathway-mediated pyroptosis, and caspase-3-induced pyroptosis. Pyroptosis has been reported to play an important role in many tissues and organs, including the liver. Autophagy is a highly conserved process of the eukaryotic cell cycle. It plays an important role in cell survival and maintenance by degrading organelles, proteins and macromolecules in the cytoplasm. Therefore, the dysfunction of this process is involved in a variety of pathological processes. In recent years, autophagy and pyroptosis and their interactions have been proven to play an important role in various physiological and pathological processes, and have gradually attracted more and more attention to become a research hotspot. Therefore, this review summarized the role of autophagy and pyroptosis in liver disorders, and analyzed the related mechanism to provide a basis for future research.

【 授权许可】

Unknown