Discovering and deciphering relationships across disparate data modalities

eLife

Eric W Bridgeford¹  Mauro Maggioni²  Joshua T Vogelstein²  Cencheng Shen²  Carey E Priebe²  Qing Wang² 

[1] Child Mind Institute, New York, United States;Johns Hopkins University, Baltimore, United States;

关键词: statistics;    machine learning;    data science;   

DOI  :  10.7554/eLife.41690

来源: DOAJ

【 摘 要 】

Understanding the relationships between different properties of data, such as whether a genome or connectome has information about disease status, is increasingly important. While existing approaches can test whether two properties are related, they may require unfeasibly large sample sizes and often are not interpretable. Our approach, ‘Multiscale Graph Correlation’ (MGC), is a dependence test that juxtaposes disparate data science techniques, including k-nearest neighbors, kernel methods, and multiscale analysis. Other methods may require double or triple the number of samples to achieve the same statistical power as MGC in a benchmark suite including high-dimensional and nonlinear relationships, with dimensionality ranging from 1 to 1000. Moreover, MGC uniquely characterizes the latent geometry underlying the relationship, while maintaining computational efficiency. In real data, including brain imaging and cancer genetics, MGC detects the presence of a dependency and provides guidance for the next experiments to conduct.

【 授权许可】

Unknown