Immunotherapy for Glioblastoma: Current State, Challenges, and Future Perspectives

Cancers

Minfeng Yang¹  InYoung Oh¹  Arpan Mahanty¹  JungSun Yoo¹  Wei-Lin Jin² 

[1] Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong;Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic, Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;

关键词: glioblastoma;    immune-checkpoint inhibitors;    tumor microenvironment;    tumor-associated macrophages and microglia;    immune-related adverse events;   

DOI  :  10.3390/cancers12092334

来源: DOAJ

【 摘 要 】

Glioblastoma is the most lethal intracranial primary malignancy by no optimal treatment option. Cancer immunotherapy has achieved remarkable survival benefits against various advanced tumors, such as melanoma and non-small-cell lung cancer, thus triggering great interest as a new therapeutic strategy for glioblastoma. Moreover, the central nervous system has been rediscovered recently as a region for active immunosurveillance. There are vibrant investigations for successful glioblastoma immunotherapy despite the fact that initial clinical trial results are somewhat disappointing with unique challenges including T-cell dysfunction in the patients. This review will explore the potential of current immunotherapy modalities for glioblastoma treatment, especially focusing on major immune checkpoint inhibitors and the future strategies with novel targets and combo therapies. Immune-related adverse events and clinical challenges in glioblastoma immunotherapy are also summarized. Glioblastoma provides persistent difficulties for immunotherapy with a complex state of patients’ immune dysfunction and a variety of constraints in drug delivery to the central nervous system. However, rational design of combinational regimens and new focuses on myeloid cells and novel targets to circumvent current limitations hold promise to advent truly viable immunotherapy for glioblastoma.

【 授权许可】

Unknown