Cortical organization of inhibition-related functions and modulation by psychopathology

Frontiers in Human Neuroscience

Anna S Engels¹  Stacie L. Warren²  Jeffrey Martin Spielberg³  Marie T Banich⁴  Bradley P Sutton⁶  Wendy eHeller⁶  Laura D. Crocker⁶  Gregory A Miller⁷ 

[1] Pennsylvania State University;St. Louis Department of Veteran Affairs;University of California, Berkeley;University of Colorado at Boulder;University of Delaware;University of Illinois Urbana Champaign;University of Konstanz;

关键词: Anxiety;    Depression;    inhibition;    attentional control;    DLPFC;   

DOI  :  10.3389/fnhum.2013.00271

来源: DOAJ

【 摘 要 】

Individual differences in inhibition-related functions have been implicated as risk factors for a broad range of psychopathology, including anxiety and depression. Delineating neural mechanisms of distinct inhibition-related functions may clarify their role in the development and maintenance of psychopathology. The present study tested the hypothesis that activity in common and distinct brain regions would be associated with an ecologically sensitive, self-report measure of inhibition and a laboratory performance measure of prepotent response inhibition. Results indicated that sub-regions of DLPFC distinguished measures of inhibition, whereas left inferior frontal gyrus and bilateral inferior parietal cortex were associated with both types of inhibition. Additionally, co-occurring anxiety and depression modulated neural activity in select brain regions associated with response inhibition. Results imply that specific combinations of anxiety and depression dimensions are associated with failure to implement top-down attentional control as reflected in inefficient recruitment of posterior DLPFC and increased activation in regions associated with threat (MTG) and worry (BA10). Present findings elucidate possible neural mechanisms of interference that could help explain executive control deficits in psychopathology.

【 授权许可】

Unknown