Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

eLife

Sophia Porter¹  L David Sibley²  Qiuling Wang³  Prabhakar Andhey⁴  Marco Colonna⁴  Kenneth M Murphy⁴  Konstantin Zaitsev⁴  Wayne M Yokoyama⁴  Maxim Artyomov⁴  Maxwell Hershey⁴  Eugene Oltz⁴  Eugene Park⁵  Beatrice Plougastel-Douglas⁵  Michael Bern⁵  Patrick Collins⁵  Swapneel Patel⁵ 

[1] Computer Technologies Department, ITMO University, Saint Petersburg, Russia;Department of Microbial Infection and Immunity, Ohio State University Wexner School of Medicine, Columbus, United States;Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, United States;Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, United States;Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, United States;

关键词: NK cells;    ILC;    toxoplasma;   

DOI  :  10.7554/eLife.47605

来源: DOAJ

【 摘 要 】

Innate lymphoid cells (ILCs) were originally classified based on their cytokine profiles, placing natural killer (NK) cells and ILC1s together, but recent studies support their separation into different lineages at steady-state. However, tumors may induce NK cell conversion into ILC1-like cells that are limited to the tumor microenvironment and whether this conversion occurs beyond this environment remains unknown. Here, we describe Toxoplasma gondii infection converts NK cells into ILC1-like cells that are distinct from both steady-state NK cells and ILC1s in uninfected mice. These cells were Eomes-dependent, indicating that NK cells can give rise to Eomes– Tbet-dependent ILC1-like cells that circulate widely and persist independent of ongoing infection. Moreover, these changes appear permanent, as supported by epigenetic analyses. Thus, these studies markedly expand current concepts of NK cells, ILCs, and their potential conversion.

【 授权许可】

Unknown