Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans

Vaccines

Karin Loré¹  Alberto Cagigi¹ 

[1] Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 161 64 Solna, Sweden;

关键词: mRNA vaccine;    dendritic cell;    protein translation;    type I interferon;    Th1 polarization;    antibody response;   

DOI  :  10.3390/vaccines9010061

来源: DOAJ

【 摘 要 】

In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.

【 授权许可】

Unknown