Vitamin D, Chronic Migraine, and Extracranial Pain: Is There a Link? Data From an Observational Study

Frontiers in Neurology

Lucia Princiotta Cariddi¹  Marco Mauri²  Maria Laura Tanda³  Maurizio Versino³  Eliana Piantanida³  Daniela Gallo³  Payam Tabaee Damavandi⁴  Elisa Candeloro⁶  Federico Carimati⁶  Valentina Rebecchi⁶  Alessandro Clemenzi⁶  Paola Banfi⁶  Marco Gallazzi⁶ 

[1] Clinical and Experimental Medicine and Medical Humanities, Center of Research in Medical Pharmacology, University of Insubria, Varese, Italy;Department of Biotechnologies and Life Sciences, University of Insubria, Varese, Italy;Department of Medicine and Surgery, University of Insubria, Varese, Italy;Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy;Endocrine Unit, University of Insubria, Varese, Italy;Neurology and Stroke Unit, ASST Sette Laghi di Varese, Varese, Italy;

关键词: chronic migraine;    episodic migraine;    headache;    allodynia;    vitamin D;   

DOI  :  10.3389/fneur.2021.651750

来源: DOAJ

【 摘 要 】

Several studies focused on the role of vitamin D (vitD) in pain chronification. This study focused on vitD level and pain chronification and extension in headache disorders. Eighty patients with primary headache underwent neurological examination, laboratory exams, including serum calcifediol 25(OH)D, and headache features assessment along with three questionnaires investigating depression, anxiety, and allodynia. The 86.8% of the population had migraine (48% episodic and 52% chronic). The 44.1% of patients had extracranial pain, and 47.6% suffered from allodynia. A vitD deficit, namely a serum 25(OH)D level <20 ng/ml, was detectable in 46.1% of the patients, and it occurred more frequently (p = 0.009) in patients suffering from chronic migraine (CM)–medication overuse migraine (MOH) (62.9%) than in episodic migraine (EM, 25.7%) or tension-type headache (TTH, 11.4%). The occurrence of extracranial pain and allodynia was higher in the CM-MOH than in the EM and in the TTH groups but was not related to the co-occurrence of vitD deficiency (Fisher's exact test p = 0.11 and p = 0.32, respectively). Our findings show that 25(OH)D deficit is also related to chronic headache, probably because of vitD anti-inflammatory and tolerogenic properties, reinforcing the idea of a neuroinflammatory mechanism underpinning migraine chronification.

【 授权许可】

Unknown