Labdane Diterpenes from the Fruits of Sinopodophyllum emodi

Molecules

Mei-Ling Gao¹  Jun-Min Wang¹  Yu Wang¹  Yan-Jun Sun²  Tao Liu²  Yan-Li Zhang²  Ya Wu² 

[1] Chinese Medicine Development of Henan Province, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China;;Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &

关键词: Sinopodophyllum emodi;    labdane diterpene;    cytotoxic activity;   

DOI  :  10.3390/molecules21040434

来源: DOAJ

【 摘 要 】

Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1–4 represents the first report of diterpenes from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated in comparison with 5-fluorouracil against the MCF-7 and HepG2 cell lines, towards which 3 showed more potent cytotoxicity.

【 授权许可】

Unknown