Self-organized patterning of cell morphology via mechanosensitive feedback

eLife

Suzanne Eaton¹  Marko Popović²  Romina Piscitello-Gómez³  K Venkatesan Iyer⁴  Jana F Fuhrmann⁵  Frank Jülicher⁶  Natalie A Dye⁶ 

[1] Center for Systems Biology Dresden, Dresden, Germany;Cluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany;Max Planck Institute for the Physics of Complex Systems, Dresden, Germany;Mildred Scheel Nachwuchszentrum (MSNZ) P2, Medical Faculty, Technische Universität Dresden, Dresden, Germany;Institute of Physics, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland;Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany;

关键词: mechanosensitivity;    patterning;    morphogenesis;    self-organization;    laser ablation;    myosinVI;   

DOI  :  10.7554/eLife.57964

来源: DOAJ

【 摘 要 】

Tissue organization is often characterized by specific patterns of cell morphology. How such patterns emerge in developing tissues is a fundamental open question. Here, we investigate the emergence of tissue-scale patterns of cell shape and mechanical tissue stress in the Drosophila wing imaginal disc during larval development. Using quantitative analysis of the cellular dynamics, we reveal a pattern of radially oriented cell rearrangements that is coupled to the buildup of tangential cell elongation. Developing a laser ablation method, we map tissue stresses and extract key parameters of tissue mechanics. We present a continuum theory showing that this pattern of cell morphology and tissue stress can arise via self-organization of a mechanical feedback that couples cell polarity to active cell rearrangements. The predictions of this model are supported by knockdown of MyoVI, a component of mechanosensitive feedback. Our work reveals a mechanism for the emergence of cellular patterns in morphogenesis.

【 授权许可】

Unknown