Journey to the Market: The Evolution of Biodegradable Drug Delivery Systems

Applied Sciences

Felicity Y. Han¹  Andrew K. Whittaker¹  Maree T. Smith²  Minze Zhu³ 

[1] Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD 4072, Australia;School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD 4072, Australia;School of Pharmacy, Faculty of Health and Behavioural Sciences, University of Queensland, Brisbane, QLD 4102, Australia;

关键词: biodegradable materials;    biopolymer;    liposome;    encapsulation methods;    degradation mechanisms;    therapeutic products;   

DOI  :  10.3390/app12020935

来源: DOAJ

【 摘 要 】

Biodegradable polymers have been used as carriers in drug delivery systems for more than four decades. Early work used crude natural materials for particle fabrication, whereas more recent work has utilized synthetic polymers. Applications include the macroscale, the microscale, and the nanoscale. Since pioneering work in the 1960’s, an array of products that use biodegradable polymers to encapsulate the desired drug payload have been approved for human use by international regulatory agencies. The commercial success of these products has led to further research in the field aimed at bringing forward new formulation types for improved delivery of various small molecule and biologic drugs. Here, we review recent advances in the development of these materials and we provide insight on their drug delivery application. We also address payload encapsulation and drug release mechanisms from biodegradable formulations and their application in approved therapeutic products.

【 授权许可】

Unknown