Length-dependent changes of lower limb muscle morphology in Chronic Inflammatory Demyelinating Polyneuropathy assessed with magnetic resonance imaging

European Journal of Translational Myology

Charles Rice¹  Timothy J. Doherty²  Kevin J. Gilmore³  Jacob Fanous⁴  Alexander M. Zero⁴ 

[1] Department of Physical Medicine and Rehabilitation, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON;Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada ;Department of Surgery, University of Toronto, Toronto, ON;School of Kinesiology, The University of Western Ontario, London, ON;

关键词: Chronic inflammatory demyelinating polyneuropathy;    CIDP;    muscle quality;    muscle composition;    MRI;   

DOI  :  10.4081/ejtm.2021.10200

来源: DOAJ

【 摘 要 】

The objective of the present study was to assess muscle quantity of the thigh and leg in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) compared to age and sex matched controls in exploring length-dependent changes of innervated muscles. In five people with CIDP and seven controls, magnetic resonance imaging was used to assess muscle morphology of the four parts of the quadriceps and medial hamstring muscles. Findings were compared to the triceps surae from a subset of participants. The CIDP group had less contractile tissue in the quadriceps (11.5%, P<0.05), hamstrings (15.6%, P<0.05) and triceps surae (35.9%, P<0.05) compared to controls. Additionally, CIDP had less contractile tissue (18.7%) in the triceps surae compared to the hamstrings (P<0.05). Muscle quantity in the quadriceps and hamstrings in CIDP was less than controls, but differences were greater for the distal triceps surae. These findings support a length-dependent affect of CIDP on limb musculature composition.

【 授权许可】

Unknown