Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous Disease

JACC: Case Reports

Shinji Kishimoto, MD, PhD¹  Yukihito Higashi, MD, PhD²  Tatsuya Maruhashi, MD, PhD³ 

[1] Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan;Address for correspondence: Prof. Yukihito Higashi, Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.;Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan;

关键词: chronic granulomatous disease;    endothelial function;    gp91phox;    NADPH oxidase;    nitric oxide;    oxidative stress;   

DOI  :  

来源: DOAJ

【 摘 要 】

Two patients with X-linked chronic granulomatous disease without NAPDH oxidase activity and with high responses of flow-mediated vasodilation are reported. Bone marrow transplantation restored oxidative stress to the levels of those in healthy subjects and decreased flow-mediated vasodilation to the levels of those in healthy subjects in both of the patients. (Level of Difficulty: Advanced.)

【 授权许可】

Unknown