Salivary cytokine profile in patients with oral lichen planus

Journal of Dental Sciences

Hong Hua¹  Xiao-Meng Ren²  Mi-Mi Zhou³  Qian-Ming Chen⁴  Chun-Lei Li⁵  Zheng-Da Zhu⁶ 

[1]Beijing Key Laboratory of Digital Stomatology &

[2]National Center of Stomatology &

[3]National Clinical Research Center for Oral Diseases &

[4]National Engineering Laboratory for Digital and Material Technology of Stomatology &

[5]Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &

[6]Department of Oral Medicine, Peking University School and Hospital of Stomatology &

关键词: Oral lichen planus;    Saliva;    Cytokine profile;    Cell-mediated immune response;    Pathogenesis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background/purpose: Oral lichen planus (OLP) is a chronic inflammatory lesion of oral mucosal, and its pathogenesis involves immune cell-mediated aberrances. However, the findings conflict with each other. This research aimed to comprehensively detect the salivary cytokine profile of patients with OLP. Materials and methods: The cohort included 60 OLP patients (30 reticular and 30 erosive), and 30 healthy controls, matched in age and sex. Human Cytokine/Chemokine Magnetic Bead Panel Kit (HCYTMAG-60K-PX41) was used to detect salivary inflammation-related cytokines. Rank sum test, group t-test, and ANOVA were used for data analysis in different groups. Moreover, Spearman's rank correlation analysis was used to analyze the correlation between salivary cytokine levels and OLP lesion severity. Results: The levels of TNF-α, G-GSF, IL-1α, IL-1β and IL-8 were statistically significant higher in both erosive and reticular OLP patients than in the healthy group, while the IL-13 level was significantly lower. Particularly, the salivary TNF-α, GM-CSF, MIP-1α, MIP-1β, IL-1β, IL-6 and IL-8 levels were higher in erosive OLP group than other groups. Spearman's rank correlation analysis revealed that the salivary TNF-α, GM-CSF, MIP-1α, MIP-1β, IL-1β and IL-6 levels were positively correlated with OLP lesion severity. Conclusion: Imbalance of the Th1/Th2-mediated immune response contributes to OLP. Certain salivary cytokines, such as MIP-1α, MIP-1β, GM-CSF, and IL-6, are positively correlated with OLP severity, and they have a high potential as biomarkers to diagnose and predict OLP prognosis.

【 授权许可】

Unknown