CML/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty Liver

Frontiers in Medicine

Zhongqun Wang¹  Honghua Cai²  Chen Shao³  Lin Wang³  Lili Zhang³  Zhen Sun³  Qiwen Pang³  Lele Jing³  Zhengyang Bao⁴  Lihua Li⁵ 

[1] ;Department of Burn Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, China;Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, China;Department of Internal Medicine, Affiliated Hospital of Wuxi Maternity and Child Health of Nanjing Medical University, Wuxi, China;Department of Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang, China;

关键词: atherosclerosis (AS);    non-alcoholic fatty liver disease (NAFLD);    Nε-carboxymethyllysine (CML);    advanced glycosylation end-product receptor (RAGE);    pro-inflammatory;   

DOI  :  10.3389/fmed.2020.583943

来源: DOAJ

【 摘 要 】

Non-alcoholic fatty liver disease (NAFLD) has become a common chronic disease in the world. NAFLD is not only a simple intrahepatic lesion, but also affects the occurrence of a variety of extrahepatic complications. In particular, cardiovascular complications are particularly serious, which is the main cause of death in patients with NAFLD. To study the relationship between NAFLD and AS may be a new way to improve the quality of life in patients with NAFLD. As we all known, inflammatory response plays an important role in the occurrence and development of NAFLD and AS. In this study, we found that the accumulation of Nε-carboxymethyllysine (CML) in the liver leads to hepatic steatosis. CML can induce the expression of interleukin (IL-1β), interleukin (IL-6), tumor necrosis factor (TNF-α), C-reactionprotein (CRP) by binding with advanced glycosylation end-product receptor (RAGE) and accelerate the development of AS. After silencing RAGE expression, the expression of pro-inflammatory cytokines was inhibited and liver and aorta pathological changes were relieved. In conclusion, CML/RAGE signal promotes the progression of non-alcoholic fatty liver disease and atherosclerosis. We hope to provide new ideas for the study of liver vascular dialogue in multi organ communication.

【 授权许可】

Unknown