Modeling and Analysis of a Microresonating Biosensor for Detection of Salmonella Bacteria in Human Blood

Sensors

Preecha Yupapin¹  Faeze Sadat Mohajer²  Shahrin Hashim³  Mahdi Bahadoran⁴  Kashif Chaudhary⁴  Jalil Ali⁴  Ahmad Fakhrurrazi Ahmad Noorden⁴  Muhammad Safwan Aziz⁴ 

[1] Advance Research Center for Photonics, Faculty of Science King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand;Bioinformatics Research Group, Universiti Teknologi Malaysia (UTM),81310 Johor Bahru, Malaysia;Economy Research Alliance (RAKE), Universiti Teknologi Malaysia (UTM),81310 Johor Bahru, Malaysia;Institute of Advance Photonics Science, Nanotechnology Research Alliance, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Malaysia;

关键词: nonlinear optics;    microring resonator;    biophotonics;    biosensor;    Salmonella bacteria;   

DOI  :  10.3390/s140712885

来源: DOAJ

【 摘 要 】

A new photonics biosensor configuration comprising a Double-side RingAdd-drop Filter microring resonator (DR-ADF) made from SiO2-TiO2 material is proposed for the detection of Salmonella bacteria (SB) in blood. The scattering matrix method using inductive calculation is used to determine the output signal’s intensities in the blood with and without presence of Salmonella. The change in refractive index due to the reaction of Salmonella bacteria with its applied antibody on the flagellin layer loaded on the sensing and detecting microresonator causes the increase in through and dropper port’s intensities of the output signal which leads to the detection of SB in blood. A shift in the output signal wavelength is observed with resolution of 0.01 nm. The change in intensity andshift in wavelength is analyzed with respect to the change in the refractive index which contributes toward achieving an ultra-high sensitivity of 95,500 nm/RIU which is almost two orders higher than that of reported from single ring sensors and the limit of detection is in the order of 1 × 10−8 RIU. In applications, such a system can be employed for a high sensitive and fast detection of bacteria.

【 授权许可】

Unknown