Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Journal of Diabetes Investigation

Terry Lee¹  Maha A Al‐Mohaissen²  Ali Faris Alamri³ 

[1] Center for Health Evaluation and Outcome Sciences Vancouver British Columbia Canada;Department of Clinical Sciences, Cardiology Princess Nourah Bint Abdulrahman University Riyadh Saudi Arabia;Department of Family Medicine King Abdullah bin Abdulaziz University Hospital Princess Nourah bint Abdulrahman University Riyadh Saudi Arabia;

关键词: Hemoglobin A1c;    Prediabetes;    Vitamin D;   

DOI  :  10.1111/jdi.13226

来源: DOAJ

【 摘 要 】

Abstract Aims/Introduction Vitamin D levels are negatively correlated with prediabetes risk and hemoglobin A1c levels in individuals with prediabetes. The data are, however, scarce and inconsistent among different populations. We aimed to assess the association of vitamin D with prediabetes risk and hemoglobin A1c levels in young Saudi women with normoglycemia and prediabetes. Materials and Methods We analyzed the data of individuals without diabetes (without diabetes history and hemoglobin A1c <6.4%) from the Princess Nourah bint Abdulrahman University’s non‐communicable diseases student registry. Demographic data, anthropometric and blood pressure measurements, and hemoglobin A1c and vitamin D results were retrieved and analyzed. Results In total, 345 participants were included in the analysis. The prediabetes status showed no association with vitamin D levels, but it was significantly associated with the participants’ weight and body mass index. Additionally, there was no correlation between the levels of vitamin D and hemoglobin A1c across the whole population, even after correction for body mass index. However, in the body mass index subgroups, when individuals with potentially harmful levels of vitamin D (>125 nmol/L) were excluded, a positive association was detected between vitamin D and hemoglobin A1c levels in the underweight individuals. Hemoglobin A1c values showed a positive correlation only with bodyweight and body mass index. Conclusions Vitamin D levels did not predict prediabetes status and showed no correlation with hemoglobin A1c levels in this population. Vitamin D levels’ effect on the risk of prediabetes might be small compared with other well‐established risk factors, such as obesity.

【 授权许可】

Unknown