Applications of Ketogenic Diets in Patients with Headache: Clinical Recommendations

Nutrients

Grazia Semeraro¹  Giulio Sirianni¹  Riccardo Garbo²  Andrea Bernardini²  Mariarosaria Valente²  Giovanni Spera³  Cherubino Di Lorenzo⁴  Gianluca Coppola⁴  Mackenzie C. Cervenka⁵  Maria Pia Prudenzano⁶  Fabio Frediani⁷  Giacomo D’Arrigo⁷  Piero Barbanti⁸  Gabriella Egeo⁸  Giulia Pierangeli⁹  Giovanna Ballerini^1,10  Nicoletta Rebaudengo^1,11 

[1] Associazione Eupraxia, Dietary Section, 00171 Rome, Italy;Clinical Neurology Unit, Misericordia University Hospital, Santa Maria Della Misericordia University Hospital, 33100 Udine, Italy;Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy;Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, 04100 Latina, Italy;Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;Headache Center, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70124 Bari, Italy;Headache Center, Neurology & Stroke Unit, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, 20142 Milan, Italy;Headache and Pain Unit, IRCCS San Raffaele Pisana, 00163 Rome, Italy;IRCCS Istituto Delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy;Multidisciplinary Center for Pain Therapy, Piero Palagi Hospital, USL Toscana Centro, 50122 Florence, Italy;Neurology Service, Humanitas Gradenigo, 10153 Turin, Italy;

关键词: ketogenic diets;    ketosis;    ketones;    clinical recommendations;    headache;    migraine;   

DOI  :  10.3390/nu13072307

来源: DOAJ

【 摘 要 】

Headaches are among the most prevalent and disabling neurologic disorders and there are several unmet needs as current pharmacological options are inadequate in treating patients with chronic headache, and a growing interest focuses on nutritional approaches as non-pharmacological treatments. Among these, the largest body of evidence supports the use of the ketogenic diet (KD). Exactly 100 years ago, KD was first used to treat drug-resistant epilepsy, but subsequent applications of this diet also involved other neurological disorders. Evidence of KD effectiveness in migraine emerged in 1928, but in the last several year’s different groups of researchers and clinicians began utilizing this therapeutic option to treat patients with drug-resistant migraine, cluster headache, and/or headache comorbid with metabolic syndrome. Here we describe the existing evidence supporting the potential benefits of KDs in the management of headaches, explore the potential mechanisms of action involved in the efficacy in-depth, and synthesize results of working meetings of an Italian panel of experts on this topic. The aim of the working group was to create a clinical recommendation on indications and optimal clinical practice to treat patients with headaches using KDs. The results we present here are designed to advance the knowledge and application of KDs in the treatment of headaches.

【 授权许可】

Unknown