High-intensity focused ultrasound in the management of adenomyosis: long-term results from a single center

International Journal of Hyperthermia

Xilei Li¹  Min Xue²  Mingzhu Ye²  Xinliang Deng²  Huihua Li²  Zhaoying Jiang²  Xiaogang Zhu²  Sili He²  Xingbo Tian²  Wenxin Long² 

[1] Department of Anesthesiology and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University;Department of Gynaecology, Third Xiangya Hospital, Central South University;

关键词: adenomyosis;    high-intensity focused ultrasound;    dysmenorrhea;    menorrhagia;    long-term outcomes;   

DOI  :  10.1080/02656736.2021.1886347

来源: DOAJ

【 摘 要 】

Objective To investigate the long-term clinical outcomes of patients with adenomyosis treated by high-intensity focused ultrasound (HIFU). Materials and methods From June 2012 to January 2020, 2311 patients with adenomyosis were treated with HIFU at our center, 1982 patients who have complete clinical data were retrospectively reviewed. Among the patients who completed the follow-up, 485 were treated with HIFU alone, 289 were treated with HIFU followed by GnRH-a, 255 were treated with HIFU combined with Mirena and 594 were treated with HIFU combined with GnRH-a and Mirena. The dysmenorrhea severity pain score and average menorrhagia severity score before and at 3 months, 6 months, 1 year, 2 years, 3 years and 5 years after HIFU were compared. The adverse effects were recorded. In addition, the efficacy between patients treated with GnRH-a and/or Mirena were compared. Results After HIFU ablation, the dysmenorrhea severity pain score and the menorrhagia severity score were significantly decreased at each follow-up time point. However, it was observed that as the follow-up time increased, the effective rate of HIFU treatment in improving dysmenorrhea and menorrhagia decreased. The 6 months and 3 years follow-up results showed that the efficacy of HIFU combined with Mirena and HIFU combined with GnRH-a and Mirena were significantly higher than HIFU alone and HIFU combined with GnRH-a (p < 0.05). The major complications were rare. Conclusion HIFU is a safe and effective treatment for patients with adenomyosis. HIFU combined with Mirena or HIFU combined with GnRH-a and Mirena can significantly enhance the long-term treatment results.

【 授权许可】

Unknown