Poly(4-vinylpyridinium)hydrogen sulfate: An efficient and recyclable Bronsted acid catalyst for the synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones

Journal of Saudi Chemical Society

B. Janardhan¹  B. Rajitha¹  Peter A. Crooks² 

[1] Department of Chemistry, National Institute of Technology, Warangal, AP, India;Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA;

关键词: 3,4-Dihydropyrimidin-2(1H)-ones;    One-pot multicomponent condensation;    Poly(4-vinylpyridinium)hydrogen sulfate;    Solvent free conditions;    Thiones;   

DOI  :  10.1016/j.jscs.2012.10.007

来源: DOAJ

【 摘 要 】

Fused ring 3,4-dihydropyrimidin-2(1H)-ones and thiones were synthesized by the one-pot three component condensation of 6-methoxy-1-tetralone, aromatic aldehydes and urea or thiourea under solvent-free conditions at 120 °C utilizing poly(4-vinylpyridinium)hydrogen sulfate as Bronsted acid catalyst. This methodology has an advantage of good yields, shorter reaction times, straight forward workup and reusability of the catalyst over five additional times without losing its activity and product yield.

【 授权许可】

Unknown