Frizzled Receptors as Potential Therapeutic Targets in Human Cancers

International Journal of Molecular Sciences

Zhe Chen¹  Chui-Mian Zeng²  Li Fu³ 

[1] Disease Prevention, Department of Pharmacology and Carson International Cancer Research Centre, Shenzhen University School of Medicine, Shenzhen 518060, China;;Guangdong Key Laboratory for Genome Stability &Zhejiang Key Laboratory of Gastro-Intestinal Pathophysiology, Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Hangzhou 310006, China;

关键词: frizzled receptors;    WNT signaling pathway;    cancer therapy;    antibody;    small molecule inhibitor;   

DOI  :  10.3390/ijms19051543

来源: DOAJ

【 摘 要 】

Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cell proliferation, formation of neural synapses, and many other processes in developing and adult organisms. In this review, we will introduce the basic structural features and review the biological function and mechanism of FZDs in the progression of human cancers, followed by an analysis of clinical relevance and therapeutic potential of FZDs. We will focus on the development of antibody-based and small molecule inhibitor-based therapeutic strategies by targeting FZDs for human cancers.

【 授权许可】

Unknown