Advanced chronic lymphoid leukemia with severe bronchopneumonia: an Autopsy Case Report

Autopsy and Case Reports

Amaro Nunes Duarte-Neto¹  Sheila Aparecida Coelho Siqueira²  Felipe Gomes Campos Amaral²  Luiz Guilherme Cernaglia Aureliano Lima³  Veruska Menegatti Anastacio Hatanaka³ 

[1] University of São Paulo. Faculty of Medicine. Anatomic Pathology Department - University of São Paulo. Faculty of Medicine. Hospital das Clínicas. Emergency Department;University of São Paulo. Faculty of Medicine. Anatomic Pathology Department;University of São Paulo. Faculty of Medicine. Instituto do Câncer do Estado de São Paulo;

关键词: Leukemia;    Lymphocytic;    Chronic;    B-Cell;    Respiratory Insufficiency;    Pneumonia;   

DOI  :  10.4322/acr.2016.022

来源: DOAJ

【 摘 要 】

Chronic lymphocytic leukemia (CLL) is a lymphoid neoplasia with the B immunophenotype, which corresponds to the leukemic form of lymphocytic lymphoma. This entity is characterized, in most cases, by immunosuppression due to impaired function of immune cells, hypogammaglobulinemia, bone marrow infiltration, and immune dysfunction due to the neoplasia and the chemotherapy, when prescribed. We describe the case of a 63-year-old woman with a previous diagnosis of advanced CLL, refractory to treatment, who presented respiratory failure at the emergency department and died soon after hospital admission. The autopsy examination showed a large retroperitoneal mass compressing large vessels and abdominal and pelvic organs; generalized lymphadenopathy; and liver, spleen, bone marrow, heart and kidney infiltration. A Gram-negative bacilli bronchopneumonia with diffuse alveolar damage was detected, which was likely to be the immediate cause of death

【 授权许可】

Unknown