Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases

Frontiers in Cell and Developmental Biology

Zheng Zhang¹  Runze Wang¹  Cuixiu Peng¹  Ning Li¹  Lin Hou¹  Jinyu Zhang¹  Zhongliang Ma²  Jinlian Song³  Yanan Hua⁴ 

[1] Department of Biochemistry and Molecular Biology, Basic Medical College, Qingdao University, Qingdao, China;Department of Breast Surgery, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China;Department of Laboratory, Women and Children’s Hospital of Qingdao, Qingdao, China;Department of Neurobiology, Basic Medical College, Qingdao University, Qingdao, China;

关键词: RRS1;    ribosome;    disease;    cancer;    molecular mechanism;   

DOI  :  10.3389/fcell.2021.620925

来源: DOAJ

【 摘 要 】

A regulator of ribosome synthesis 1 (RRS1) was discovered in yeast and is mainly localized in the nucleolus and endoplasmic reticulum. It regulates ribosomal protein, RNA biosynthesis, and protein secretion and is closely involved in cellular senescence, cell cycle regulation, transcription, translation, oncogenic transformation etc., Mutations in the RRS1 gene are associated with the occurrence and development of Huntington’s disease and cancer, and overexpression of RRS1 promotes tumor growth and metastasis. In this review, the structure, function, and mechanisms of RRS1 in various diseases are discussed.

【 授权许可】

Unknown