Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications

International Journal of Molecular Sciences

Valentina Salvi¹  Mattia Laffranchi¹  Ilaria Barbazza¹  Daniela Bosisio¹  AnnalisaDel Prete¹  Tiziana Schioppa¹  Francesca Sozio¹  Laura Tiberio¹  Silvano Sozzani²  Angela Gismondi² 

[1] Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy;Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy;

关键词: dendritic cell subsets;    cancer;    tumor microenvironment;    cancer immunotherapy;    migration;    cytokines;   

DOI  :  10.3390/ijms21113930

来源: DOAJ

【 摘 要 】

Dendritic cells (DCs) constitute a complex network of cell subsets with common functions but also with many divergent aspects. All dendritic cell subsets share the ability to prime T cell response and to undergo a complex trafficking program related to their stage of maturation and function. For these reasons, dendritic cells are implicated in a large variety of both protective and detrimental immune responses, including a crucial role in promoting anti-tumor responses. Although cDC1s are the most potent subset in tumor antigen cross-presentation, they are not sufficient to induce full-strength anti-tumor cytotoxic T cell response and need close interaction and cooperativity with the other dendritic cell subsets, namely cDC2s and pDCs. This review will take into consideration different aspects of DC biology, including the functional role of dendritic cell subsets in both fostering and suppressing tumor growth, the mechanisms underlying their recruitment into the tumor microenvironment, as well as the prognostic value and the potentiality of dendritic cell therapeutic targeting. Understanding the specificity of dendritic cell subsets will allow to gain insights on role of these cells in pathological conditions and to design new selective promising therapeutic approaches.

【 授权许可】

Unknown