Multi-Facial, Non-Peptidic α-Helix Mimetics

Biology

Steven Fletcher¹  Maryanna E. Lanning¹ 

[1] Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St., Baltimore, MD 21201, USA;

关键词: α-helix mimetic;    protein–protein interaction;    proteomimetic;    amphipathic;    cancer;    Bcl-2;    HMD2;    Bak;    Bim;    p53;   

DOI  :  10.3390/biology4030540

来源: DOAJ

【 摘 要 】

α-Helices often recognize their target proteins at protein–protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple faces of an α-helix.

【 授权许可】

Unknown