Diagnostic Value of 18F-FDG-PET/CT in Patients with FUO

Journal of Clinical Medicine

Paraskevi Exadaktylou¹  Dimitrios Katsampoukas¹  Vasilios Mpalaris¹  Georgios Arsos¹  Ioannis Petrou¹  Efstratios-Iordanis Moralidis¹  Stamata Georga¹  Christos Papastergiou²  Kostoula Arvaniti³ 

[1] 3rd Department of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, Greece;Department of Radiology, Papageorgiou General Hospital, 56403 Thessaloniki, Greece;ICU and Antimicrobial Stewardship Unit, Papageorgiou General Hospital, 56403 Thessaloniki, Greece;

关键词: fever of unknown origin;    FUO;    PET/CT;    ¹⁸F-FDG-PET/CT;   

DOI  :  10.3390/jcm9072112

来源: DOAJ

【 摘 要 】

Conventional diagnostic imaging is often ineffective in revealing the underlying cause in a considerable proportion of patients with fever of unknown origin (FUO). The aim of this study was to assess the diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT) in patients with FUO. We retrospectively reviewed ¹⁸F-FDG-PET/CT scans performed on 50 consecutive adult patients referred to our department for further investigation of classic FUO. Final diagnosis was based on histopathological and microbiological findings, clinical criteria, or clinical follow-up. Final diagnosis was established in 39/50 (78%) of the patients. The cause of FUO was infection in 20/50 (40%), noninfectious inflammatory diseases in 11/50 (22%), and malignancy in 8/50 (16%) patients. Fever remained unexplained in 11/50 (22%) patients. ¹⁸F-FDG-PET/CT scan substantially contributed to the diagnosis in 70% of the patients, either by identifying the underlying cause of FUO or by directing to the most appropriate site for biopsy. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of ¹⁸F-FDG-PET/CT for active disease detection in patients with FUO were 94.7%, 50.0%, 84.0%, 85.7%, and 75.0%, respectively. In conclusion, whole-body ¹⁸F-FDG-PET/CT is a highly sensitive method for detection of the underlining cause of FUO or for correctly targeting suspicious lesions for further evaluation.

【 授权许可】

Unknown