Coumarin–Tetrapyrrolic Macrocycle Conjugates: Synthesis and Applications

Molecules

Ana F. R. Cerqueira¹  Vítor A. S. Almodôvar¹  Maria G. P. M. S. Neves¹  Augusto C. Tomé¹ 

[1] Department of Chemistry and QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal;

关键词: coumarins;    porphyrins;    phthalocyanines;    corroles;   

DOI  :  10.3390/molecules22060994

来源: DOAJ

【 摘 要 】

This review covers the synthesis of coumarin–porphyrin, coumarin–phthalocyanine and coumarin–corrole conjugates and their potential applications. While coumarin–phthalocyanine conjugates were obtained almost exclusively by tetramerization of coumarin-functionalized phthalonitriles, coumarin–porphyrin and coumarin–corrole conjugates were prepared by complementary approaches: (a) direct synthesis of the tetrapyrrolic macrocycle using formylcoumarins and pyrrole or (b) by functionalization of the tetrapyrrolic macrocycle. In the last approach a range of reaction types were used, namely 1,3-dipolar cycloadditions, hetero-Diels–Alder, Sonogashira, alkylation or acylation reactions. This is clearly a more versatile approach, leading to a larger diversity of conjugates and allowing the access to conjugates bearing one to up to 16 coumarin units.

【 授权许可】

Unknown