National Effort to Re-Establish Heavy Ion Cancer Therapy in the United States

Frontiers in Oncology

Harald Paganetti¹  Robert L. Foote²  Quynh Thu Le³  Hak Choy⁴  Arnold Pompos⁴  Albert C. Koong⁵  Radhe Mohan⁶ 

[1] Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, United States;Department of Radiation Oncology, Mayo Clinic, Rochester, MN, United States;Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States;Department of Radiation Oncology, University of Texas (UT) Southwestern Medical Center, Dallas, TX, United States;Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States;Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX, United States;

关键词: heavy ion;    cancer therapy;    carbon ion;    radiotherapy;    particle radiotherapy;   

DOI  :  10.3389/fonc.2022.880712

来源: DOAJ

【 摘 要 】

In this review, we attempt to make a case for the establishment of a limited number of heavy ion cancer research and treatment facilities in the United States. Based on the basic physics and biology research, conducted largely in Japan and Germany, and early phase clinical trials involving a relatively small number of patients, we believe that heavy ions have a considerably greater potential to enhance the therapeutic ratio for many cancer types compared to conventional X-ray and proton radiotherapy. Moreover, with ongoing technological developments and with research in physical, biological, immunological, and clinical aspects, it is quite plausible that cost effectiveness of radiotherapy with heavier ions can be substantially improved.

【 授权许可】

Unknown