Neurorestorative therapy for stroke

Frontiers in Human Neuroscience

michael echopp¹  Poornima eVenkat¹  Jieli eChen² 

[1] Oakland University;henry ford hospital;

关键词: microRNA;    neurorestoration;    Bone marrow stromal cell (BMSC);    Human umbilical cord blood cell (HUCBC);    Niaspan;   

DOI  :  10.3389/fnhum.2014.00382

来源: DOAJ

【 摘 要 】

Ischemic stroke is a major cause of death and long-term disability world wide. Development of effective therapy has been the target of intense research. Accumulating preclinical literature has shown that substantial functional improvement after stroke can be achieved using subacutely administered cell-based and pharmacological therapies. This review provides an update on bone marrow-derived mesenchymal stem cells (BMSCs), human umbilical cord blood cells (HUCBCs) and select pharmacological agents presently in clinical use for other indications, to promote recovery processes in the sub-acute and chronic phases after stroke. This review paper also focuses on molecular mechanisms underlying the cell-based and pharmacological restorative processes which enhance angiogenesis, arteriogenesis, neurogenesis and white matter remodeling following cerebral ischemia as well as an analysis of the interaction/coupling among these restorative events. In addition, the role ofmicroRNAs (miRNAs) mediating the intercellular communication between exogenously administered cells and parenchymal cells, and their effects onthe regulation of angiogenesis and neuronal progenitor cell proliferation and differentiation, andbrain plasticity after stroke will be described.

【 授权许可】

Unknown