Plasmatic Klotho and FGF23 Levels as Biomarkers of CKD-Associated Cardiac Disease in Type 2 Diabetic Patients

International Journal of Molecular Sciences

Nelson Tavares¹  HugoMendonça Café¹  Nélio Santos²  Fátima Rato²  Carolina Dias³  RuiBaptista Gonçalves³  Edgar Almeida⁴  André Fragoso⁵  Pedro Leão Neves⁵  Filipa Mendes⁵  Eduarda Carias⁵  AnaPaula Silva⁵ 

[1]Cardiology Department, Centro Hospitalar Universitário do Algarve, 8000-386 Faro, Portugal

[2]Clinic Pathology Department, Centro Hospitalar Universitário do Algarve, 8000-836, Faro, Portugal

[3]Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 8005-139 Faro, Portugal

[4]Faculdadade de Medicina da Universidade de Lisboa, 1600-190 Lisboa, Portugal

[5]Nephrology Department, Centro Hospitalar Universitário do Algarve, 800-836 Faro, Portugal

关键词: klotho;    FGF-23;    CKD;    CVD;    LVMI;   

DOI  :  10.3390/ijms20071536

来源: DOAJ

【 摘 要 】

Background: Research over the past decade has focused on the role of Klotho as a cardio protective agent that prevents the effects of aging on the heart and reduces the burden of cardiovascular disease CVD. The role of the interaction between fibroblast growth factor 23-(FGF-23)/Klotho in Klotho-mediated actions is still under debate. The main objective was to ascertain the potential use of plasmatic Klotho and FGF23 as markers for CKD-associated cardiac disease and mortality. Methods: This was a prospective analysis conducted in an outpatient diabetic nephropathy clinic, enrolling 107 diabetic patients with stage 2–3 CKD. Patients were divided into three groups according to their left ventricular mass index and relative wall thickness. Results: Multinomial regression analysis demonstrated that low Klotho and higher FGF-23 levels were linked to a greater risk of concentric hypertrophy. In the generalized linear model (GLM), Klotho, FGF-23 and cardiac geometry groups were statistically significant as independent variables of cardiovascular hospitalization (p = 0.007). According to the Cox regression model, fatal cardiovascular events were associated with the following cardiac geometric classifications; eccentric hypertrophy (p = 0.050); concentric hypertrophy (p = 0.041), and serum phosphate ≥ 3.6 mg/dL (p = 0.025), FGF-23 ≥ 168 (p = 0.0149), α-klotho < 313 (p = 0.044). Conclusions: In our population, Klotho and FGF23 are associated with cardiovascular risk in the early stages of CKD.

【 授权许可】

Unknown