Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases

Molecules

Areha Abid¹  Tapan Behl²  Simona Bungau³  Bianca Pasca³  AnamariaLavinia Purza³  DeliaMirela Tit³  CosminMihai Vesa⁴  Laura Endres⁵  LauraMaghiar Todan⁶ 

[1] Department of Food Science, Faculty of Agricultural and Food Sciences, University of Debrecen, 4032 Debrecen, Hungary;Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India;Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania;Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania;Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania;Doctoral School of Biomedical Sciences, University of Oradea, 410073 Oradea, Romania;

关键词: Withania somnifera;    withaferin A;    dermatology;    dermatological disorders;    melanoma;    Ayurvedic medicine;   

DOI  :  10.3390/molecules26092407

来源: DOAJ

【 摘 要 】

Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity—numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies.

【 授权许可】

Unknown