Event-Related Desynchronization/Synchronization in Spinocerebellar Ataxia Type 3

Frontiers in Neurology

Jui-Cheng Chen¹  Masashi Hamada²  Yu Aoh³  Han-Jun Hsiao³  Ming-Kuei Lu⁴  Chon-Haw Tsai⁴  Hui-Chun Huang⁴  Antonella Macerollo⁵ 

[1] Department of Neurology, China Medical University Hsinchu Hospital, Hsinchu, Taiwan;Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung City, Taiwan;School of Medicine, College of Medicine, China Medical University, Taichung City, Taiwan;Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom;

关键词: ERD;    ERS;    cerebellar ataxia;    SCA3;    motor control;   

DOI  :  10.3389/fneur.2019.00822

来源: DOAJ

【 摘 要 】

Introduction: Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant, cerebellar degeneration predominant disease caused by excessive CAG repeats. We examined event-related dysynchronization/synchronization (ERD/ERS) in patients with SCA3.Methods: We assessed ERD/ERS of self-paced voluntary hand movements in 15 patients with genetically proven SCA3 in comparison with healthy controls.Results: In ERS, a significant interaction effect between group, frequency, and period (F = 1.591; p = 0.005; ρI = 0.86) was observed. The post-hoc two-tailed independent t-test showed significant differences in high beta and low beta ERS. By contrast, in ERD, no apparent differences were observed in the pattern of patients with SCA3 in comparison with healthy controls (F = 1.01; p = 0.442).Conclusion: The study revealed a decreased ERS in patients with SCA3, especially at the frequency of 20–30 Hz. This study elucidates the significant role of cerebellum in motor control.

【 授权许可】

Unknown