The relationship between inspiratory lung function parameters and airway hyper-responsiveness in subjects with mild to moderate COPD

BMC Research Notes

关键词: Chronic obstructive pulmonary disease;    Forced expiratory volume 1 second;    Inspiratory lung functions parameters;    Visual analogue scale;   

DOI  :  10.1186/1756-0500-5-209

来源: DOAJ

【 摘 要 】

Abstract

Background

The aim of this study was to evaluate the effects of increasing doses of inhaled histamine on the forced expiratory volume in one second (FEV₁), inspiratory lung function parameters (ILPs) and dyspnea in subjects with mild to moderate chronic obstructive pulmonary disease (COPD)

Methods

Thirty-nine (27 males and 12 females) stable COPD patients (GOLD stages I and II) inhaled a maximum of six sequential doses of histamine according to ERS standards until one of these provocative doses produced a 20% decrease in FEV₁ (PD₂₀). The effects on the FEV₁, the forced inspiratory volume in one second (FIV₁), inspiratory capacity (IC), forced inspiratory flow at 50% of the vital capacity (FIF50), peak inspiratory flow (PIF) and dyspnea score by a visual analogue scale (VAS) were measured and investigated after each dose step

Results

After each dose of histamine, declines in all of the lung function parameters were detected; the largest decrease was observed in the FEV₁. At the PD₂₀ endpoint, more FEV₁ responders than ILP responders were found. Among the ILPs, the FIV₁ and IC best predicted which patients would reach the PD₂₀ endpoint. No significant correlations were found between any of the lung function parameters and the VAS results

Conclusions

In COPD patients, the FEV₁ and ILPs declined after each dose of inhaled histamine. FEV₁ was more sensitive to histamine than the ILPs. Of the ILPs, FIV₁ and IC were the best predictors of reaching the PD₂₀ endpoint. No statistically significant correlations were found between the lung function parameters and the degree of dyspnea

【 授权许可】

Unknown