Interferon-Lambda 1 Inhibits Staphylococcus aureus Colonization in Human Primary Keratinocytes

Frontiers in Pharmacology

Ying Gu¹  Yan Zhao²  Xia Wu²  Xiaojie Wang²  Kun Li²  Jianzhong Zhang² 

[1] Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;Department of Dermatology, Peking University People’s Hospital, Beijing, China;

关键词: interferon-lambda 1;    Staphylococcus aureus;    atopic dermatitis;    keratinocyte;    reactive oxygen species;    signal transducerand activator of transcription 1;   

DOI  :  10.3389/fphar.2021.652302

来源: DOAJ

【 摘 要 】

Atopic dermatitis (AD) is a common inflammatory skin disease. Staphylococcus aureus (S. aureus) colonization in skin lesions occurs in approximately 70% of AD patients. It has been found that IFN-λ1 can inhibit the colonization of S. aureus in normal human nasal mucosa. IFN-λ1 can increase IL-28RA in infected human keratinocytes. In this study, we found that IFN-λ1 can increase mRNA expression of FLG and antimicrobial peptides (AMPs) and inhibit TSLP mRNA expression in infected human keratinocytes. IFN-λ1 can increase intracellular ROS level, decrease STAT1 phosphorylation, and inhibit the colonization of S. aureus in human primary keratinocytes. These effects were attenuated by knocking-down IL-28R and NADPH oxidase inhibitor, suggesting that this function was mediated by JAK-STAT1 signaling pathway. These results suggest that IFN-λ1 might have an inhibitory effect on S. aureus colonization in AD lesions. Our findings might have potential value in the treatment for AD.

【 授权许可】

Unknown